- Research & Clinical Trials
- Cutting-Edge Alzheimer’s Research
- The 90+ Study
- Down Syndrome Program
- Clinical Trials
Down Syndrome Program
Down syndrome is the most common cause of genetically-determined intellectual disability in the United States, affecting approximately 1 in 700 live births. An estimated 350,000 Americans have Down syndrome. Also called trisomy 21, Down syndrome results from a tripling of all or part of the 21st chromosome. The association between Down syndrome and Alzheimer’s disease was established in 1948. Since then, we’ve learned that by age 40, all individuals with trisomy 21 have the characteristic amyloid plaques and neurofibrillary tangles of Alzheimer’s disease. Individuals with Down syndrome constitute the only population we know that has these ubiquitous changes of Alzheimer’s disease by mid-adult life.
For more information about the UCI MIND Down Syndrome program contact:
Eric Doran, M.S.
Manager, Down Syndrome Program
UC Irvine Medical Center
To read more about the link between Alzheimer’s disease and Down syndrome, see the articles below: