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Inflammation is a fundamental protective response of the body. If it becomes dysregulated, inflammation can be a major cofactor in the pathogenesis of many chronic human conditions, including Alzheimer disease. Recent analyses of genome wide association studies have identified at least eight human genes related to inflammation that increase risk for Alzheimer’s disease. Hence, there is a critical relationship between inflammation and Alzheimer’s disease.
Inflammation is a key and invariant pathological feature of Alzheimer’s disease pathology, and its impact on disease progression and neurodegeneration remains an area of active investigation here at UCI MIND. Because of the prominent role of inflammation, a large number of faculty labs are specifically investigating the role of inflammation in Alzheimer’s disease as part of a cross-disciplinary team-based approach.
Inflammatory cells in the brain and their potential role in Alzheimer’s disease.