About the Alzheimer’s Disease Research Center


Senior Neuropsychologist, Dr. Malcolm B. Dick

The UCI Alzheimer’s Disease Research Center (ADRC) was officially established in 2000 and has received a continuing annual appropriation of 1.2 million dollars from the National Institute on Aging (NIA). The UCI ADRC is one of several multi-disciplinary and multi-investigator grants administered by the Institute for Memory Impairments and Neurological Disorders.

Part of the Institute for Memory Impairments and Neurological Disorders at UCI MIND, our ADRC is one of 29 NIA-funded Alzheimer’s disease centers across the country. Involving over 100 investigators, the UCI ADRC has directed its research efforts at discovering the cellular, molecular and clinical risk factors that precipitate neuronal dysfunction and neuropathological changes in the aging brain and can result in Alzheimer’s disease or another dementia. Since inception, the UCI ADRC has generated 350 peer-reviewed and 17 review articles in variety of highly regarded scientific journals. Together the 29 centers, each with its own research emphasis, offer a network for sharing findings, germinating new ideas, and developing collaborative studies that draw upon the expertise of scientists from across the nation.

ADRC Mission Statement


Medical Director of the Memory Assessment Research Center, Dr. Aimee Pierce

The mission of the UCI ADRC is to encourage multidisciplinary basic, clinical, and behavioral research in Alzheimer’s disease and translate findings into practice. As part of this mission, the ADRC trains scientists and health care providers who are new to Alzheimer’s disease research and provides education about Alzheimer’s disease and the related dementias throughout the community.

Our Goals

As Orange County’s only federally funded Alzheimer’s disease center, UCI ADRC seeks to translate research advances into improved diagnosis, treatment, and care for people living with mild cognitive impairment (MCI) Alzheimer’s disease or another dementia today and ultimately find a way to cure and possibly prevent these conditions. Our goals are to:

  • Describe the cognitive and underlying brain changes that differentiate normal aging, Mild Cognitive Impairment (MCI), and Alzheimer’s disease
  • Investigate ways to identify, diagnose, and treat Alzheimer’s disease and related disorders
  • Better understand cognitive aging in special populations, including the oldest old and persons with Down syndrome
  • Engage older adults in a variety of studies on memory and aging
  • Serve as the expert source of information on memory and aging for Orange County seniors, health care professionals, and aging service providers, as well as the community at large.


Helps families affected by Mild Cognitive Impairment (MCI), Alzheimer's disease, or another dementia while gathering invaluable research data about the clinical presentation and progression of these cognitive disorders.
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Education and Information
Garners community involvement in research, combats the widespread lack of knowledge about Alzheimer’s disease through a variety of education and outreach activities.
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Was it really Alzheimer’s disease? This is the most important question that the Neuropathology Component addresses upon the death of a research volunteer for the children and grandchildren who are concerned about developing dementia.
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Data Management and Statistics
Responsible for transferring our ADRC data to the National Alzheimer’s Coordinating Center which houses and makes available data from all 29 Alzheimer’s disease centers to researchers worldwide.
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Responsible for high-level planning, coordinating the five components and any research projects funded through the ADRC, attracting and nurturing the development of new investigators, and managing all ADRC operational requirements.
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